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Vyas and Mirji: A rare case of pregnancy with gaucher%u2019s diseaseMOGS Chronicles | Volume 1 | Issue 1 | September 2024 9%u00a9 The Author(s). 2024 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons. org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/ zero/1.0/) applies to the data made available in this article, unless otherwise stated.metabolized strongly by hepatic CYP2D6 %u2013 enzymes and to a lesser extent by CYP3A. Thus, all inhibitors of these pathways may increase toxicity of eligustat and should be avoided. Also special care should be taken in patient positioning and transfer in view of possible osteopenia.ConclusionIn conclusion, this case demonstrates the importance of thorough initial assessment and multidisciplinary team approach goes a long way in successful management of pregnancy with Gaucher%u2019s disease. It also underscores the need for more research and studies in this area for a better understanding of this condition in pregnancy.DeclarationConflict of interestNone.DisclosureNone.Informed consentInformed consent Informed consent was taken from the patient.References1. Available from: https://rarediseases.org/rare-diseases/gaucherdisease [Last accessed on 2024 Sep 09].2. Sidransky E. Available from: https://emedicine.medscape.com/How to cite this article: Vyas P, Mirji S. A Rare Case of Pregnancy with Gaucher%u2019s Disease. MOGS Chronicles 2024;1(1):7-9.GD is a rare genetic disorder that affects the body%u2019s ability to metabolize certain substances. It can complicate pregnancy with complications like, bone deformities, anemia, thrombocytopenia, and neurological issues.This case report highlights the challenges of managing pregnancy in a patient with Type 1 GD, emphasizing the need of a multidisciplinary approach. Diagnosis can be done by measurement of glucocerebrosidase activity in peripheral blood leucocytes. Monitoring is done by CBC, LFT and coagulation profile. USG abdomen for organomegaly, X-ray or MRI for skeletal deformities, DEXA scans for osteopenia. Treatment of Type 1 GD comprises of ERT. Regional anaesthesia is preferred unless it is precluded by severe thrombocytopenia. The successful management of anemia and thrombocytopenia, along with careful monitoring and timely interventions are crucial for a good maternal and fetal outcome.Editor%u2019s Notearticle/944157-print [Last accessed on 2023 Oct ???].3. Komninaka V, Flevari P, Marinakis T, Karkaletsis G, Malakou L, Repa K. Outcomes of pregnancies in patients with Gaucher%u2019s disease: The experience of a center of excellence on rare metabolic disease- Gaucher Disease in Greece. Eur J Obstet Gynecol Reprod Biol 2020;254:181-7.